What is CAR T-Cell Therapy?
CAR T-Cell Therapy, an immunotherapy, is a novel therapy that helps a person's immune system recognize and fight cancer. The immune system is responsible for ridding the body of abnormal cells that are foreign (like cancer) or infected and T-lymphocytes (T-Cells) are a type of cell responsible for killing abnormal cells. During the CAR T-Cell treatment process, T-Cells are drawn from a patient's blood and genetically modified to recognize and fight their own cancer cells when reinfused.
Here's how it works:
- First, a patient's white blood cells are collected through a process called apheresis
- Then, the T-Cells are isolated from other blood cells.
- T-Cells are then modified in a special facility to help them recognize and target the cancer cells, what can be thought of as "fighter" T-Cells.
- Lastly, the new "fighter" T-Cells are reinfused into the patient to allow tumor cell recognition.
CAR T-Cell Therapy is best administered in transplant centers that are FACT-accredited; Medical City's Blood and Marrow Transplant Program, a member of the Sarah Cannon Blood Cancer Network, has been accredited since 2004 and has a comprehensive care team specially trained in this exciting new therapy. It has FDA approved CAR T-Cell Therapy now available in the following disease sites:
- Adult Diffuse Large B-Cell Lymphoma (DLBCL)
- Pediatric and Adolescent B-Cell Acute Lymphoblastic Leukemia (ALL)
To learn more about CAR T-Cell Therapy, a type of immunotherapy, and potential treatment options for you, contact:
Taryn Holder, Lead Transplant Coordinator at Medical City Dallas Hospital at (972) 566-6468