What is CAR T-Cell Therapy?

CAR T-Cell Therapy, an immunotherapy, is a novel therapy that helps a person's immune system recognize and fight cancer. The immune system is responsible for ridding the body of abnormal cells that are foreign (like cancer) or infected and T-lymphocytes (T-Cells) are a type of cell responsible for killing abnormal cells. During the CAR T-Cell treatment process, T-Cells are drawn from a patient's blood and genetically modified to recognize and fight their own cancer cells when reinfused.

Here's how it works:

  1. First, a patient's white blood cells are collected through a process called apheresis
  2. Then, the T-Cells are isolated from other blood cells.
  3. T-Cells are then modified in a special facility to help them recognize and target the cancer cells, what can be thought of as "fighter" T-Cells.
  4. Lastly, the new "fighter" T-Cells are reinfused into the patient to allow tumor cell recognition.

CAR T-Cell Therapy, Immunotherapy, CAR T, Sarah Cannon Blood Cancer Network I Immune Effector Cell Therapy

FDA-Approved Therapy

CAR T-Cell Therapy is best administered in transplant centers that are FACT-accredited; Medical City's Blood and Marrow Transplant Program, a member of the Sarah Cannon Blood Cancer Network, has been accredited since 2004 and has a comprehensive care team specially trained in this exciting new therapy. It has FDA approved CAR T-Cell Therapy now available in the following disease sites:

  • Adult Diffuse Large B-Cell Lymphoma (DLBCL)
  • Pediatric and Adolescent B-Cell Acute Lymphoblastic Leukemia (ALL)

Referral Information

To learn more about CAR T-Cell Therapy, a type of immunotherapy, and potential treatment options for you, contact:

Taryn Holder, Lead Transplant Coordinator at Medical City Dallas Hospital at (972) 566-6468