New Blood & Marrow Transplant Referral
Understanding Blood & Marrow Transplant
As a member of the Sarah Cannon Blood Cancer Network, Medical City Dallas has access to a number of quality, infrastructure, training and research resources. Watch this animated video to understand the process of a blood and marrow, or stem cell, transplant.
Trasplante de sangre y médula ósea 101: Mire este vídeo animado para comprender el proceso de un trasplante de sangre y médula ósea o célula madre. Como miembro de Sarah Cannon Blood Cancer Network, nuestro programa tiene acceso a un número de recursos de calidad, infraestructura, capacitación e investigación.
Frequently Asked Questions
As you’re considering or preparing for a blood or marrow transplant (BMT), you may have a lot of questions. These videos produced and provided by Be The Match®, a Sarah Cannon Blood Cancer Network partner, can help you understand what to expect before, during and after a BMT. Remember, each person has their own experience with transplant and no two patients follow the exact same path. Your path will depend on many factors, including type of transplant, your overall health and your disease status. Your Medical City Dallas transplant team from will support you throughout the entire process.
Bone marrow, peripheral blood stem cell (PBSC), and cord blood provide different sources of cells for transplantation.
Why a good Human Leukocyte Antigen (HLA) match is critical.
Engraftment of donated cells is an important recovery milestone.
Graft-Versus-Host Disease (GVHD) is a common side effect of an allogeneic transplant.
Leading-Edge Oncological Care
Patients diagnosed with blood cancers such as leukemia, lymphoma, myeloma or other blood disorders may benefit from a blood or marrow transplant, also known as stem cell therapy. Medical City Dallas is a shining example of the latest in oncological care. We are the only hospital in North Texas that performs both adult and pediatric stem cell transplants, including autologous (stem cells from self), allogeneic (stem cells from donor) and transplants using cells from umbilical cord blood. Our goal is to provide hope for prolonged survival and a cure for patients with cancer and blood disorders.
What is stem cell transplant?
Stem cell transplantation is a procedure that restores stem cells that have been destroyed by high doses of chemotherapy or radiation therapy. Three types of transplants are available:
- Autologous transplant: Patients receive their own stem cells. Your stem cells or marrow are collected, frozen and stored. When needed, the stem cells are thawed and infused into you. The cells or marrow can be stored for years after freezing.
- Syngeneic transplant: Patients receive stem cells from their identical twin.
- Allogeneic transplant: Patients receive stem cells or marrow from a donor. The donor could be a sibling or a person who is not related to the patient. Blood tests, called Human Leukocyte Antigen (HLA) typing, determine the degree of compatibility between the patient and a donor. An HLA-matched, unrelated donor may be identified through the National Marrow Donor Program using a computerized list of volunteer donors.
Hematopoietic, or blood-forming, stem cells divide to form three types of blood cells: white blood cells, which fight infection; red blood cells, which carry oxygen; and platelets, which help the blood to clot. Most hematopoietic stem cells are found in the bone marrow, but some cells, called peripheral blood stem cells (PBSCs), are found in the bloodstream. The umbilical cord also contains hematopoietic stem cells. The source of stems cells you will receive will depend on the type of transplant and your donor’s options.
Prior to stem cell transplantation, patients receive very high doses of chemotherapy and/or radiation therapy. The chemotherapy is called "high dose" because the doses are five to 10 times higher than the doses given during standard chemotherapy. Chemotherapy and radiation therapy generally affect cells that divide rapidly, thus targeting cancer cells. After chemotherapy and radiation therapy is given, the patient is given the donor cells, or transplant, so as to create a new immune system altogether.
The healthy transplanted stem cells can restore the bone marrow’s ability to produce the blood cells needed. Autologous transplant patients donate their cells prior to high dose chemotherapy and/or radiation therapy. Allogeneic transplant donors usually donate cells on the day before or the day of transplant. If transplanted stem cells come from an umbilical cord, the cord will arrive at the Stem Cell Laboratory prior to the start of high dose chemotherapy and/or radiation therapy.
From clinical workup to transplantation, each facet of our stem cell program is accredited by the Foundation for the Accreditation of Cellular Therapy (FACT). To ensure access to international registries, which increases our chances of locating donors, we have a partnership with the National Marrow Donor Program (NMDP). In addition, our Stem Cell Laboratory is FDA registered and accredited by the American Association of Blood Banks (AABB).