Anemia of Chronic Disease
(Anemia of Inflammation; Hypoferremia of Inflammatory Disease; ACD)
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- Chronic infections, such as tuberculosis , lung abscess, and subacute endocarditis
- Noninfectious inflammatory diseases, such as rheumatoid arthritis , osteomyelitis , systemic lupus erythematosus, and inflammatory bowel disease
- Common childhood infections, including ear infections and urinary tract infections
- Congestive heart failure , thyroid disease, and kidney failure
- Cancer, particularly Hodgkin’s disease , lung cancer , and breast cancer
- Pale complexion, lightheadedness, fatigue, and rapid heartbeat
- Blood tests
- A bone marrow biopsy
Iron Disorders Institute http://www.irondisorders.org
National Heart, Lung, and Blood Institute http://www.nhlbi.nih.gov
Canadian Cancer Society http://www.cancer.ca
Health Canada http://www.hc-sc.gc.ca
Beutler E. Unlocking the mysteries of iron homeostasis and of the anemia of chronic disease: is hepcidin the key? Blood. 2003;102:775.
Weiss G, Goodnough, LT. Anemia of chronic disease. NEJM. 2005;352:1011-1023.
What is anemia? National Heart Lung and Blood Institute website. Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/anemia/. Updated May 18, 2012. Accessed August 19, 2014.
3/12/2008 DynaMed Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Bennett CL, Silver SM, Djulbegovic B, et al. Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia. JAMA. 2008;299:914-924.
9/2/2009 DynaMed Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Bohlius J, Schmidlin K, Brillant C, et al. Erythropoietin or Darbepoetin for patients with cancer—meta-analysis based on individual patient data. Cochrane Database Syst Rev. 2009;(3):CD007303.
- Reviewer: Marcin Chwistek, MD
- Review Date: 08/2014 -
- Update Date: 08/19/2014 -
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
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