Principal Proposed Uses
- Stress ; Mental Function
What Is the Scientific Evidence for L-Theanine?
1 L-theanine. Memorial Sloan-Kettering Cancer Center website. Available at: http://www.mskcc.org/mskcc/html/69285.cfm . Updated December 10, 2010. Accessed August 15, 2011.
2 Sugiyama T, Sadzuka Y. Combination of L-theanine with doxorubicin inhibits hepatic metastasis of M5076 ovarian sarcoma. Clin Cancer Res . 1999;5(2):413-416.
3 Sadzuka Y, Sugiyama T, Sonobe T. Improvement of idarubicin induced antitumor activity and bone marrow suppression by L-theanine, a component of tea. Cancer Lett . 2000;158(2):119-124.
4 Juneja LR. Suntheanine and its relaxation effect in humans. Trends in Food Science & Tech . 1999;10;199-204.
5 Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr . 2008;17 Suppl 1:167-168.
6 Park SK, Jung IC, Lee WK, et al. A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. J Med Food . 2011;14(4):334-343.
7 Ritsner MS, Miodownik C, Ratner Y, et al. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. J Clin Psychiatry . 2011;72(1):34-42.
8 Giesbrecht T, Rycroft JA, Rowson MJ, De Bruin EA. The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci . 2010;13(6):283-290.
9 Einöther SJ, Martens VE, Rycroft JA, De Bruin EA. L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness. Appetite . 2010;54(2):406-409.
10 Owen GN, Parnell H, De Bruin EA, Rycroft JA. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci . 2008;11(4):193-198.
11 Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB. The effects of L-theanine, caffeine, and their combination on cognition and mood. Biol Psychol . 2008;77(2):113-122.
12 Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol . 2007;74(1):39-45.
13 Miyagawa K, Hayashi Y, Kurihara S, Maeda A. Co-administration of l-cystine and l-theanine enhances efficacy of influenza vaccination in elderly persons: nutritional status-dependent immunogenicity. Geriatr Gerontol Int . 2008;8(4):243-250.
- Reviewer: EBSCO CAM Review Board
- Review Date: 08/2013 -
- Update Date: 11/18/2014 -
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