Multiple System Atrophy
(MSA; Sporadic Olivopontocerebellar Atrophy; Shy-Drager Syndrome; Parkinson’s Plus Syndrome; Multi-system Degeneration; Multi-system Atrophy; Idiopathic Autonomic Failure; Idiopathic Orthostatic Hypotension;)
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- Type MSA-A is associated with orthostatic hypotension. This is a problem managing blood pressure when moving from sitting to standing. It can lead to lightheadedness or fainting.
Type MSA-P is associated with symptoms similar to initial Parkinson symptoms such as:
- Slow, stiff movements
- Clumsiness—loss of balance and coordination
Type MSA-C is associated with:
- Difficulty swallowing
- Problems speaking and hoarseness
- Difficulty coordinating muscle movement
- Problems with bladder control
- Erectile dysfunction
- Muscle tightening around a joint that prevents free movement
- Problems with posture, such as leaning to one side and forward head bend
- Inappropriate laughing or crying
- Excess yawning
- Vision problems
- Changes in writing
- Blood tests
- Lumbar puncture
- Relieve muscle rigidity
- Stabilize mood
- Manage orthostatic hypotension
- Relieve other symptoms such as constipation, urinary control problems, or erectile dysfunction
- Physical therapy—to help keep muscles strong and maintain range of motion
- Occupational therapy—to improve ability to do daily tasks such as eating, grooming, and dressing
- Speech therapy—to help with speaking and swallowing
- Respiratory therapy— Continuous positive airway pressure (CPAP) for sleep apnea and other breathing problems during sleep
National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov
The Multiple System Atrophy Coalition https://www.multiplesystematrophy.org
Canadian Institutes of Health Research http://www.cihr-irsc.gc.ca
Health Canada http://www.hc-sc.gc.ca
Multiple system atrophy. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated August 27, 2014. Accessed November 30, 2014.
Multiple system atrophy fact sheet. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/msa/detail%5Fmsa.htm. Updated November 5, 2014. Accessed April 19, 2013.
Multiple system atrophy/Shy-Drager syndrome. Vanderbilt University Medical Center website. Available at: http://www.mc.vanderbilt.edu/root/vumc.php?site=adc&doc=4791. Accessed November 30, 2014.
NINDS multiple system atrophy with orthostatic hypotension. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/msa%5Forthostatic%5Fhypotension/msa%5Forthostatic%5Fhypotension.htm. Updated December 5, 2013. Accessed November 30, 2014.
NINDS olivopontocerebellar atrophy information page. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/opca/opca.htm. Updated April 16, 2014. Accessed November 30, 2014.
1/20/2015 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Fanciulli A, Wenning GK. Multiple-system atrophy. N Engl J Med. 2015 Jan 15;372(3):249-263.
- Reviewer: Rimas Lukas, MD
- Review Date: 12/2014 -
- Update Date: 01/20/2015 -
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
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