Can Folic Acid Help Ease Depression?
Folic Acid and the Brain
What the Studies Have Found
Should Folic Acid Be Part of Depression Treatment?
The Bottom Line
- Fortified breakfast cerals
- Chickpeas, pinto beans, lima beans
Depression & Bipolar Support Alliance http://www.DBSAlliance.org
National Alliance for the Mentally Ill http://www.nami.org
Canadian Psychological Association http://www.cpa.ca
Health Canada Food and Nutrition http://www.hc-sc.gc.ca
Coppen A, Bailey J. Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial. J Affect Disord. 2000;60:121-130.
Depression. EBSCO DynaMed website. Available at:http://www.ebscohost.com/dynamed. Updated March 14, 2014. Accessed April 2, 2014.
Folate. EBSCO Natural and Alternative Treatments website. EBSCO Health Library website. Available at: http://www.ebscohost.com/healthLibrary. Updated August 22, 2013. Accessed April 2, 2014.
Folate. Office of Dietary Supplements website. Available at: http://ods.od.nih.gov/factsheets/folate-HealthProfessional. Updated December 14, 2012. Accessed April 2, 2014.
Gilbody S, Lightfoot T, Sheldon T. Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity. J Epidemiol Community Health. 2007;61(7):631-637.
S-Adenosylmethionine (SAMe). EBSCO Natural and Alternative Treatments website. EBSCO Health Library website. Available at: http://www.ebscohost.com/healthLibrary. Updated August 22, 2013. Accessed April 2, 2014.
Walker JG, Mackinnon AJ, Batterham P, et al. Mental health literacy, folic acid and vitamin B12, and physical activity for the prevention of depression in older adults: randomised controlled trial. Br J Psychiatry. 2010;197(1):45-54.
- Reviewer: Michael Woods, MD
- Review Date: 04/2014 -
- Update Date: 04/02/2014 -
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