Is Grapefruit Affecting Your Medications?
The Goodness in Grapefruit
How the Grapefruit/Drug Interaction Works
Give Up Grapefruit?
Which Drugs Are Affected?
|Type||Examples of Medicines|
|Calcium channel blockers||Amlodipine (eg, Norvasc)|
|Felodipine (eg, Plendil)|
|Nicardipine (eg, Cardene)|
|Nimodipine (eg, Nimotop)|
|Nisoldipine (eg, Sular)|
|Verapamil (eg, Calan, Covera-HS, Isoptin)|
|Antiarrhythmics||Amiodarone (eg, Cordarone, Pacerone)|
|Quinidine (eg, Apo-Quinidine, BioQuin, Novo-Quinidin)|
|Immunosuppressants||Cyclosporine (eg, Neoral, Sandimmune)|
|Sirolimus (eg, Rapamune)|
|Tacrolimus (eg, Prograf)|
|HMG-CoA reductase inhibitors||Atorvastatin (eg, Lipitor)|
|Lovastatin (eg, Mevacor)|
|Simvastatin (eg, Zocor)|
|HIV protease inhibitors||Saquinavir|
|Psychiatric medicines||Alprazolam (eg, Xanax)|
|Buspirone (eg, BuSpar)|
|Carbamazepine (eg, Carbatrol, Epitol, Tegretol)|
|Clomipramine (eg, Anafranil)|
|Diazepam (eg, Valium)|
|Midazolam (eg, Midazolam Syrup)|
|Sertraline (eg, Zoloft)|
|Triazolam (eg, Halcion)|
|Other medicines||Cilostazol (eg, Pletal)|
|Methadone (eg, Dolophine, Methadose)|
|Mifepristone (eg, Mifeprex)|
|Sildenafil (eg, Viagra)|
US Food and Drug Administration http://www.fda.gov/
US National Library of Medicines http://www.nlm.nih.gov/
Canadian Pharmacists Association http://www.pharmacists.ca/
Health Canada http://www.hc-sc.gc.ca/index%5Fe.html/
Grapefruit/grapefruit juce drug interaction information for health professionals. University of Florida College of Pharmacy Center for Drug Interaction Research and Education website. Available at: http://www.druginteractioncenter.org/. Accessed June 11, 2012.
Grapefruit, raw, pink and red and white, all areas. USDA National Nutrient Database for Standard Reference website. Available at: http://ndb.nal.usda.gov/ndb/foods/show/2321?fg=&man=&lfacet=&format=&count=&max=100&offset=&sort=&qlookup=grapefruit%2C+raw%2C+pink+red. Published 2010. Accessed June 12, 2012.
Medicine interactions with grapefruit: what you should know. Am Fam Physician. 2006;74(4):611. American Family Physician website. Available at: http://www.aafp.org/afp/2006/0815/p611.html. Published August 2006. Accessed June 12, 2012.
Stump AL, Mayo T, Blum A. Management of grapefruit-drug interactions. Am Fam Physician . 2006;74(4):605-608.
Verapamil. EBSCO Health Library website. Available at: http://www.ebscohost.com/healthLibrary/. Updated August 27, 2009. Accessed December 28, 2009.
Zeratsky K. Grapefruit juice: beware of dangerous medication interactions. Mayo Clinic website. Available at: http://www.mayoclinic.com/health/food-and-nutrition/AN00413. Updated November 3, 2011. Accessed June 11, 2012.
- Reviewer: Brian Randall, MD
- Review Date: 06/2012 -
- Update Date: 06/12/2012 -
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
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