Picking a Pain Reliever: Which One Should You Take?
- History of asthma, rhinitis, and nasal polyps, known as the aspirin triad
- Severe liver or kidney disease
- Bleeding disorder
- Aspirin or salicylate allergy
- Pregancy or lactation
Nonsteroidal Anti-Inflammatory Drugs Other Than Aspirin
- Have a history of bleeding disorders
- Take blood-thinning medication
- Have kidney or liver problems
- Have high blood pressure
- Have heart failure
Family Doctor—American Academy of Family Physicians http://familydoctor.org
US Food and Drug Administration http://www.fda.gov
Canadian Pharmacists Association http://www.pharmacists.ca
Health Canada http://www.hc-sc.gc.ca
Acetaminophen. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated January 29, 2014. Accessed February 10, 2015.
Aspirin. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated January 20, 2015. Accessed February 10, 2015.
Aspirin: questions and answers. US Food and Drug Administration website. Available at: http://www.fda.gov/drugs/resourcesforyou/consumers/questionsanswers/ucm071879.htm. Updated May 2, 2014. Accessed February 10, 2015.
Henderson AJ, Shaheen SO. Acetaminophen and asthma. Paediatr Respir Rev. 2013;14(1):9-15.
Ibuprofen (NSAID) pain reliever/fever reducer. Daily Med website. Available at: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ee241be0-35f8-4789-a71f-98de31d6a590. Updated June 2014. Accessed February 10, 2015.
Naproxen sodium (NSAID) pain reliever/fever reducer. Daily Med website. Available at: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ee241be0-35f8-4789-a71f-98de31d6a590. Updated June 2014. Accessed February 10, 2015.
Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol. 2002;40:3.
Lee WM. Acute liver failure in the United States. Semin Liver Dis. 2003;23:217-226.
Lee WM. Drug-induced hepatotoxicity. N Engl J Med. 1995;333:1118-1127.
Understanding your OTC options. Family Doctor—American Academy of Family Physicians website. Available at: http://familydoctor.org/familydoctor/en/drugs-procedures-devices/over-the-counter/pain-relievers-understanding-your-otc-options.html. Updated October 2013. Accessed February 9, 2015.
Zhang W, Jones A, Doherty M. Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials. Ann Rheum Dis. 2004 Aug;63(8):901-7
8/23/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Beasley R, Clayton T, Crane J, et al. Acetaminophen use and risk of asthma, rhinoconjunctivitis and eczema in adolescents: ISAAC phase three. Am J Respir Crit Care Med. 2010 Aug 13 early online.
- Reviewer: Michael Woods, MD
- Review Date: 02/2015 -
- Update Date: 02/10/2015 -
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