(ADL; Sudanophilic Leukodystrophy; Schilder’s Disease)
- Myelin sheath— the fatty insulation covering on nerve fibers in the brain
- Adrenal gland and surrounding adrenal cortex—produces vital hormones
|Myelin Sheath Around Nerve Fiber|
|Copyright © Nucleus Medical Media, Inc.|
- Childhood cerebral ALD
- Adolescent ALD
- Adult cerebral ALD
- Adrenal insufficiency-only
- Symptomatic heterozygotes
X-linked ALD (Childhood Cerebral ALD)
- Behavioral changes
- Poor memory
- A slowing down of thought processes and physical activity
- Developmental regression
- Vision loss
- Hearing loss
- Difficulty swallowing and speaking
- Difficulty with walking and coordination
- Increased pigmentation of the skin, due to adrenal hormone deficiency— Addison’s disease
- Progressive dementia
- Vegetative state or death
X-linked ALD (Adolescent Cerebral ALD)
X-linked ALD (Adult Cerebral ALD)
- Blood tests
- Genetic testing
- Physical therapy
- Psychological therapy
- Special education for children
- Bone marrow transplantation —this procedure may be most helpful when given early to boys with X-linked child-onset ALD
Dietary therapy, which includes consumption of:
- A low fat diet
- Lorenzo’s oil—dietary supplements of glycerol trioleate and glycerol trierucate
- Lovastatin—an anti-cholesterol medication
- Medications that affect interactions between DNA and other proteins
National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov
United Leukodystrophy Foundation http://www.ulf.org
Health Canada http://www.hc-sc.gc.ca
The Myelin Project of Canada http://www.myelin.org
Berger J, Pujol A, Aubourg P, Forrs-Petter S. Current and future pharmacologic treatment strategies in X-linked adrenoleukodystrophy. Brain Pathol. 2010;20(4):845-856.
Moser HW. Therapy of X-linked adrenoleukodystrophy (review). NeuroRx. 2006. Apr;3(2):246-53.
Moser HW, Raymond GV, Dubey P. Adrenoleukodystrophy: new approaches to a neurodegenerative disease. JAMA. 2005 Dec 28;294(24):3131-4.
Moser HW, Raymond GV, Lu SE, Muenz LR, Moser AB, Xu J, et al. Follow-up of 89 asymptomatic patients with adrenoleukodystrophy treated with Lorenzo's oil. Arch Neurol. 2005 Jul;62(7):1073-1080.
NINDS adrenoleukodystrophy information page. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/adrenoleukodystrophy/adrenoleukodystrophy.htm. Updated October 22, 2012. Accessed June 3, 2014.
- Reviewer: Kari Kassir, MD
- Review Date: 06/2014 -
- Update Date: 06/03/2014 -
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Copyright © EBSCO Publishing
All rights reserved.