Chronic Granulomatous Disease
(CGD; Fatal Granulomatosis of Childhood; Chronic Granulomatous Disease of Childhood; Progressive Septic Granulomatosis)
- Parents who have the recessive trait
- Sex: male
- Swollen lymph nodes in the neck
Frequent skin infections that are resistant to treatment, such as:
- Persistent diarrhea
- Bone pain
- Joint pain
|Bacterial Skin Infection|
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- Blood tests
- Biopsy and cultures
Bone Marrow Transplantation
Genetics Home Reference http://ghr.nlm.nih.gov
National Organization of Rare Disorders http://www.rarediseases.org
Health Canada http://www.hc-sc.gc.ca
Sick Kids http://www.sickkids.ca
Bernhisel-Broadbent J, Camargo EE, Jaffe HS, et al. Recombinant human interferon-gamma as adjunct therapy for Aspergillus infection in a patient with chronic granulomatous disease. J Infect Dis. 1991;163(4):908-911.
Chronic granulomatous disease. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated May 2, 2014. Accessed May 29, 2014.
Chronic granulomatous disease. Genetics Home Reference website. Available at: http://ghr.nlm.nih.gov/condition/chronic-granulomatous-disease. Updated August 2012. Accessed May 26, 2014.
Chronic granulomatous disease and other phagocytic cell disorders. Immune Deficiency Foundation website. Available at: http://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/chronic-granulomatous-disease-and-other-phagocytic-cell-disorders/. Accessed May 29, 2014.
Dinauer MC, Lekstrom-Himes JA, Dale DC. Inherited Neutrophil Disorders: Molecular Basis and New Therapies. Hematology. 2000;303.
Lekstrom-Himes JA, Gallin JI. Immunodeficiency diseases caused by defects in phagocytes. N Engl J Med. 2000; 343:1703.
Pogrebniak HW, Gallin JI, Malech HL. Surgical management of pulmonary infections in chronic granulomatous disease of childhood. Ann Thorac Surg. 1993;55(4):844-849.
- Reviewer: Kari Kassir, MD
- Review Date: 05/2014 -
- Update Date: 05/29/2014 -
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
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