- Vitamin B12 and Folate - Supplementation Possibly Helpful
1 Ermens AA, Refsum H, Rupreht J, et al. Monitoring cobalamin inactivation during nitrous oxide anesthesia by determination of homocysteine and folate plasma and urine. Clin Pharmacol Ther 49: 385–393, 1991.
2 Flippo TS and Holder WD Jr. Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B 12 deficiency. Arch Surg 128: 1391–1395, 1993.
3 Amos RJ, Amess JAL, Hinds CJ, and Mollin DL. Incidence and pathogenesis of acute megaloblastic bone-marrow change in patients receiving intensive care. Lancet 2: 835–839, 1982.
4 Shils M, et al. (eds.). Modern nutrition in health and disease, 9th ed. Baltimore: Williams and Wilkins, 1999: 1635.
5 Nunn JF, Chanarin I, Tanner AG, and Owen ER. Megaloblastic bone marrow changes after repeated nitrous oxide anesthesia. Reversal with folic acid. Br J Anaesth 58: 1469–1470, 1986.
6 Amos RJ, Amess JA, Hinds CJ, and Mollin DL. Investigations into the effect of nitrous oxide anesthesia on folate metabolism in patient receiving intensive care. Chemioterapia 4: 393–399, 1985.
7 Koblin DD, Tomerson BW, Waldman FM, et al. Effect of nitrous oxide on folate and vitamin B 12 metabolism in patients. Anesth Analg 71: 610–617, 1990.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 09/18/2014 -
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