What Is Lapacho Used for Today?
1 Li CJ, Averboukh L, Pardee AB. beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem . 1993;268:22463-22468.
2 Guiraud P, Steiman R, Campos-Takaki GM, et al. Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone. Planta Med . 1994;60:373-374.
3 Oswald EH. Lapacho. Br J Phytother . 1993/1994;3:112-117.
4 Bailly C. Topoisomerase I poisons and suppressors as anticancer drugs. Curr Med Chem. 2000;7:39-58.
5 Dolan ME, Frydman B, Thompson CB, et al. Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents. Anticancer Drugs. 1998;9:437-448.
6 Huang L, Pardee AB. Beta-lapachone induces cell cycle arrest and apoptosis in human colon cancer cells. Mol Med. 1999;5:711-720.
7 Hueber A, Esser P, Heimann K, et al. The topoisomerase I inhibitors, camptothecin and beta-lapachone, induce apoptosis of human retinal pigment epithelial cells. Exp Eye Res. 1998;67:525-530.
8 Krishnan P, Bastow KF. Novel mechanism of cellular DNA topoisomerase II inhibition by the pyranonaphthoquinone derivatives alpha-lapachone and beta-lapachone. Cancer Chemother Pharmacol. 2001;47:187-198.
9 Li Y, Li CJ, Yu D, Pardee AB. Potent induction of apoptosis by beta-lapachone in human multiple myeloma cell lines and patient cells. Mol Med. 2000;6:1008-1015.
10 Neder K, Marton LJ, Liu LF. Reaction of beta-lapachone and related naphthoquinones with 2-mercaptoethanol: a biomimetic model of topoisomerase II poisoning by quinones. Cell Mol Biol. 1998;44:465-474.
11 Planchon SM, Pink JJ, Tagliarino C, et al. Beta-lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3. Exp Cell Res. 2001;267:95-106.
12 Carvalho LH, Rocha EM, Raslan DS, et al. In vitro activity of natural and synthetic naphthoquinones against erythrocytic stages of Plamodium falciparum . Braz J Med Biol Res . 1988;21:485-487.
13 Guiraud P, Steiman R, Campos-Takaki GM, et al. Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone. Planta Med. 1994;60:373-374.
14 Lima NM, dos Santos AF, Porfirio Z, et al. Toxicity of lapachol and isolapachol and their potassium salts against Biomphalaria glabrata , Schistosoma mansoni cercariae , Artemia salina and Tilapia nilotica . Acta Trop. 2002;83:43-47.
15 Portillo A, Vila R, Freixa B, Adzet T, Canigueral S. Antifungal activity of Paraguayan plants used in traditional medicine. J Ethnopharmacol. 2001;76:93-98.
16 Santos AF, Ferraz PA, de Abreu FC, et al. Molluscicidal and trypanocidal activities of lapachol derivatives. Planta Med. 2001;67:92-93.
17 Miranda FG, Vilar JC, Alves IA, Cavalcanti SC, Antoniolli AR. Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract. BMC Pharmacol. 2001;1:6.
18 Muller K, Sellmer A, Wiegrebe W. Potential antipsoriatic agents: lapacho compounds as potent inhibitors of HaCaT cell growth. J Nat Prod. 1999;62:1134-1136.
19 Goel RK, Pathak NK, Biswas M, et al. Effect of lapachol, a naphthaquinone isolated from Tectona grandis , on experimental peptic ulcer and gastric secretion. J Pharm Pharmacol. 1987;39:138-140.
20 Guerra MO, Mazoni AS, Brandao MA, Peters VM. Interceptive effect of lapachol in rats. Contraception. 1999;60:305-307.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 09/18/2014 -
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