What Is Ginger Used for Today?
What Is the Scientific Evidence for Ginger?
Interactions You Should Know About
1 Bliddal H, Rosetzsky A, Schlichting P, et al. A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis. Osteoarthritis Cartilage. 2000;8:9-12.
2 Tyler VE. Herbs of Choice: The Therapeutic Use of Phytomedicinals . New York, NY: Pharmaceutical Products Press; 1994:42.
3 Holtmann S, Clarke AH, Scherer H, et al. The anti-motion sickness mechanism of ginger. Acta Otolaryngol . 1989;108:168-174.
4 Grontved A, Brask T, Kambskard J, et al. Ginger root against seasickness. A controlled trial on the open sea. Acta Otolaryngol . 1988;105:45-49.
5 Mowrey DB, Clayson DE. Motion sickness, ginger, and psychophysics. Lancet . 1982;1:655-657.
6 Schmid R, Schick T, Steffen R, et al. Comparison of seven commonly used agents for prophylaxis of seasickness. J Travel Med .1994;1:203-206.
7 Riebenfeld D, Borzone L. Randomized double-blind study comparing ginger (Zintona) and dimenhydrinate in motion sickness. Healthnotes Rev . 1999;6:98-101.
8 Careddu P. Motion sickness in children: results of a double-blind study with ginger (Zintona) and dimenhydrinate. Healthnotes Rev . 1999;6:102-107.
9 Stott JRR, Hubble MP, Spencer MB. A double blind comparative trial of powdered ginger root, hyosine hydrobromide, and cinnarizine in the prophylaxis of motion sickness induced by cross coupled stimulation. Advisory Group for Aerospace Research and Development, Conference Proceedings . 1985;372:1-6.
10 Stewart JJ, Wood MJ, Wood CD, et al. Effects of ginger on motion sickness susceptibility and gastric function. Pharmacology . 1991;42:111-120.
11 Wood CD, Manno JE, Wood MJ, et al. Comparison of efficacy of ginger with various antimotion sickness drugs. Clin Res Pract Drug Reg Aff . 1988;6:129-136.
12 Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstet Gynecol. 2001;97:577-582.
13 Fischer-Rasmussen W, Kjaer SK, Dahl C, et al. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol . 1991;38:19-24.
14 Bone ME, Wilkinson DJ, Young JR, et al. Ginger root: a new antiemetic. The effect of ginger root on postoperative nausea and vomiting after major gynaecological surgery. Anaesthesia . 1990;45:669-671.
15 Phillips S, Hutchinson S, Ruggier R. Zingiber officinale (ginger)—An antiemetic for day case surgery. Anaesthesia . 1993;48:715-717.
16 Arfeen Z, Owen H, Plummer JL, et al. A double-blind randomized controlled trial of ginger for the prevention of postoperative nausea and vomiting. Anaesth Intensive Care. 1995;23:449-452.
17 Visalyaputra S, Petchpaisit N, Somcharoen K, et al. The efficacy of ginger root in the prevention of postoperative nausea and vomiting after outpatient gynaecological laparoscopy. Anaesthesia . 1998;53:506-510.
18 Srivastava KC. Isolation and effects of some ginger components on platelet aggregation and eicosanoid biosynthesis. Prostaglandins Leukot Med . 1986;25:187-198.
19 Srivastava KC. Effects of aqueous extracts of onion, garlic and ginger on platelet aggregation and metabolism of arachidonic acid in the blood vascular system: in vitro study. Prostaglandins Leukot Med . 1984;13:227-235.
20 Srivastava KC. Effect of onion and ginger consumption on platelet thromboxane production in humans. Prostaglandins Leukot Essent Fatty Acids . 1989;35:183-185.
21 Janssen PL, Meyboom S, van Staveren WA, et al. Consumption of ginger ( Zingiber officinaleRoscoe ) does not affect ex vivo platelet thromboxane production in humans. Eur J Clin Nutr . 1996;50:772-774.
22 Bordia A, Verma SK, Srivastava KC. Effect of ginger ( Zingiber officinale Rosc. ) and fenugreek ( Trigonella foenumgraecum L. ) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids . 1997;56:379-384.
23 Lumb AB. Effect of dried ginger on human platelet function. Thromb Haemost . 1994;71:110-111.
24 Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001;44:2531-2538.
25 Keating A, Chez RA. Ginger syrup as an antiemetic in early pregnancy. Altern Ther Health Med. 2002;8:89-91.
26 Lien HC, Sun WM, Chen YH, et al. Effects of ginger on motion sickness and gastric slow-wave dysrhythmias induced by circular vection. Am J Physiol Gastrointest Liver Physiol . 2003;284:G481-G489.
27 Pongrojpaw D, Chiamchanya C. The efficacy of ginger in prevention of post-operative nausea and vomiting after outpatient gynecological laparoscopy. J Med Assoc Thai . 2003;86:244-250.
28 Gonlachanvit S, Chen YH, Hasler WL, et al. Ginger reduces hyperglycemia-evoked gastric dysrhythmias in healthy humans: Possible role of endogenous prostaglandins. J Pharmacol Exp Ther. 2003 Oct 8. [Epub ahead of print].
29 Sripramote M, Lekhyananda N. A randomized comparison of ginger and vitamin B6 in the treatment of nausea and vomiting of pregnancy. J Med Assoc Thai. 2003;86:846-853.
30 Morin AM, Betz O, Kranke P, et al. Is ginger a relevant antiemetic for postoperative nausea and vomiting? Anasthesiol Intensivmed Notfallmed Schmerzther . 2004;39:281-285.
31 Eberhart LH, Mayer R, Betz O, et al. Ginger does not prevent postoperative nausea and vomiting after laparoscopic surgery. Anesth Analg. 2003; 96: 995-998
32 Wigler I, Grotto I, Caspi D, Yaron M. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis Cartilage. 2003;11:783-789.
33 Kruth P, Brosi E, Fux R, et al. Ginger-associated overanticoagulation by phenprocoumon. Ann Pharmacother 2004;38:257-260.
34 Borrelli F, Capasso R, Aviello G, et al. Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Obstet Gynecol . 2005;105:849-856.
35 Manusirivithaya S, Sripramote M, Tangjitgamol S, et al. Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin. Int J Gynecol Cancer . 2004;14:1063-1069.
36 Jiang X, Williams KM, Liauw WS, et al. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol . 2005;59:425-432.
37 Apariman S, Ratchanon S, Wiriyasirivej B. Effectiveness of ginger for prevention of nausea and vomiting after gynecological laparoscopy. J Med Assoc Thai . 2006;89:2003-2009.
38 Sripramote M, Lekhyananda N. A randomized comparison of ginger and vitamin B 6 in the treatment of nausea and vomiting of pregnancy. J Med Assoc Thai. 2003;86:846-853.
39 Smith C, Crowther C, Willson K, et al. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol. 2004;103:639-645.
40 Ensiyeh J, Sakineh MA. Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: a randomised controlled trial. Midwifery. 2008 Feb 11.
41 Vutyavanich T, Wongtra-ngan S, Ruangsri R. Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. 1995;173:881-884.
42 Wu KL, Rayner CK, Chuah SK, et al. Effects of ginger on gastric emptying and motility in healthy humans. Eur J Gastroenterol Hepatol. 2008;20:436-440.
43 Alizadeh-Navaei R, Roozbeh F, Saravi M, et al. Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi Med J. 2008;29:1280-1284.
44 Zick SM, Ruffin MT, Lee J, et al. Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting. Support Care Cancer. 2008 Nov 13.
45 Cady RK, Goldstein J, Nett R, Mitchell R, Beach ME, Browning R. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic) in the treatment of migraine. Headache. 2011;51(7):1078-1086.
- Reviewer: EBSCO CAM Review Board
- Review Date: 07/2012 -
- Update Date: 07/25/2012 -
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Copyright © EBSCO Publishing
All rights reserved.