Principal Proposed Uses
What Is Chasteberry Used for Today?
What Is the Scientific Evidence for Chasteberry?
Premenstrual Syndrome (PMS)
Interactions You Should Know About
1 Milewicz A, Gejdel E, Sworen H, et al. Vitex agnuscastus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study [translated from German]. Arzneimittelforschung . 1993;43:752-756.
2 Jarry H, Leonhardt S, Gorkow C, et al. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus castus : direct evidence for a dopaminergic principle by the dopamine receptor assay. Exp Clin Endocrinol . 1994;102:448-454.
3 Sliutz G, Speiser P, Schultz AM, et al. Agnus castus extracts inhibit prolactin secretion of rat pituitary cells. Horm Metab Res . 1993;25:253-255.
4 Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physicians' Guide to Herbal Medicine . 3rd ed. Berlin, Germany: Springer-Verlag; 1998:241-242.
5 Propping D, Katzorke T, Belkien L. Diagnosis and therapy of corpus luteum insufficiency in general practice [translated from German]. Therapiewoche . 1988;38:2992-3001.
6 Gerhard I, Patek A, Monga B, et al. Mastodynon for female infertility [in German; English abstract]. Forsch Komplementarmed. 1998;5:272-278.
7 Bergmann J, Luft B, Boehmann S, et al. The effectiveness of the complex agent, Phyto-Hypophyson L, in female sterility of hormonal origin [translated from German]. Forsch Komplementarmed Klass Naturheilkd. 2000;7:190-199.
8 Halaska M, Beles P, Gorkow C, et al. Treatment of cyclical mastalgia with a solution containing a Vitex agnus castus extract: results of a placebo-controlled double-blind study. Breast . 1999;8:175-181.
9 Wuttke W, Splitt G, Gorkow C, et al. Treatment of cyclical mastalgia: results of a randomised, placebo-controlled, double-blind study [translated from German]. Geburtsh Frauenheilk . 1997;57:569-574.
10 Kubista E, Muller G, Spona J. Treatment of mastopathy associated with cyclic mastodynia: clinical results and hormone profiles [translated from German]. Gynakol Rundsch . 1986;26:65-79.
11 Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study. BMJ . 2001;322:134-137.
12 Lauritzen C, Reuter HD, Repges R, et al. Treatment of premenstrual tension syndrome with Vitex agnus castus . Controlled, double-blind study versus pyridoxine. Phytomedicine . 1997;4:183-189.
13 Kleijnen J, Ter Riet G, Knipschild P. Vitamin B6 in the treatment of premenstrual syndrome--a review. Br J Obstet Gynaecol . 1990;97:847-852.
14 Dittmar FW, Bohnert KJ, Peeters M, et al. Premenstrual syndrome: treatment with a phytopharmaceutical [translated from German]. Therapie Woche Gynakol . 1992;5:60-68.
15 Peters-Welte C, Albrecht M. Menstrual abnormalities and PMS: V itex agnus castus [translated from German]. Therapie Woche Gynakol . 1994;7:49-52.
16 Milewicz A, Gejdel E, Sworen H, et al. Vitex agnuscastus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study [translated from German]. Arzneimittelforschung . 1993;43:752-756.
17 Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physicians' Guide to Herbal Medicine . 3rd ed. Berlin, Germany: Springer-Verlag; 1998:243.
18 Cahill DJ, Fox R, Wardle PG, et al. Multiple follicular development associated with herbal medicine. Hum Reprod . 1994;9:1469-1470.
19 van Die MD, Burger HG, Bone KM, et al. Hypericum perforatum with Vitex agnus-castus in menopausal symptoms: a randomized, controlled trial. Menopause. 2008 Sep 10.
20 van Die MD, Bone KM, Burger HG, Reece JE, Teede HJ. Effects of a combination of Hypericum perforatum and Vitex agnus-castus on PMS-like symptoms in late-perimenopausal women: findings from a subpopulation analysis. J Altern Complement Med. 2009;15(9):1045-1048.
21 He Z, Chen R, Zhou Y, et al. Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China. Maturitas. 2009;63(1):99-103.
22 Ma L, Lin S, Chen R, Zhang Y, Chen F, Wang X. Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Aust N Z J Obstet Gynaecol. 2010;50(2):189-193.
23 Schellenberg R, Zimmermann C, et al. Dose-dependent efficacy of the Vitex agnus castus extract Ze 440 in patients suffering from premenstrual syndrome. Phytomedicine. 2012;19(14):1325-1331.
24 van Die MD, Burger HG, et al. Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials. Planta Med. 2013;79(7):562-575.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 09/18/2014 -
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