Congestive Heart Failure
Principal Proposed Natural Treatments
Coenzyme Q 10 (CoQ 10 )
Vitamin B 1
Other Proposed Natural Treatments
1 Hofman-Bang C, Rehnqvist N, Swedberg K, et al. Coenzyme Q 10 as an adjunctive treatment of congestive heart failure. J Am Coll Cardiol . 1992; 19:216A.
2 Morisco C, Trimarco B, Condorelli M. Effect of coenzyme Q 10 therapy in patients with congestive heart failure: a long-term multicenter randomized study. Clin Investig . 1993;71(8 suppl):S134- S136.
3 Khatta M, Alexander BS, Krichten CM, et al. The effect of coenzyme Q 10 in patients with congestive heart failure. Ann Intern Med. 2000;132:636-640.
6 Popping S, Rose H, Ionescu I, et al. Effect of a hawthorn extract on contraction and energy turnover of isolated rat cardiomyocytes. Arzneimittelforschung . 1995;45:1157-1161.
7 Joseph G, Zhao Y, Klaus W. Pharmacologic action profile of crataegus extract in comparison to epinephrine, amirinone, milrinone and digoxin in the isolated perfused guinea pig heart [in German; English abstract]. Arzneimittelforschung . 1995;45:1261-1265.
8 Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physicians' Guide to Herbal Medicine . 3rd ed. Berlin, Germany: Springer-Verlag; 1998:91-94.
9 Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physicians' Guide to Herbal Medicine . 3rd ed. Berlin, Germany: Springer-Verlag; 1998:91-94.
10 Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physicians' Guide to Herbal Medicine . 3rd ed. Berlin, Germany: Springer-Verlag; 1998:95-98.
11 Leuchtgens VH. Crataegus Special Extract WS 1442 in NYHA II heart failure. A placebo controlled randomized double-blind study [in German]. Fortschr Med. 1993;111:36-38.
12 Tauchert M, Siegel G, Schulz V. Hawthorn extract as plant medication for the heart; a new evaluation of its therapeutic effectiveness [translated from German]. MMW Munch Med Wochenschr. 1994;136(suppl 1):S3-S5.
14 Brady JA, Rock CL, Horneffer MR. Thiamin status, diuretic medications, and the management of congestive heart failure. J Am Diet Assoc. 1995;95:541-544.
15 Shimon I, Almog S, Vered Z, et al. Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy. Am J Med. 1995;98:485-490.
16 Azuma J, Hasegawa H, Sawamura A, et al. Therapy of congestive heart failure with orally administered taurine. Clin Ther. 1983;5:398-408.
17 Azuma J, Sawamura A, Awata N, et al. Double-blind randomized crossover trial of taurine in congestive heart failure. Curr Ther Res . 1983;34:543-557.
18 Azuma J, Sawamura A, Awata N, et al. Therapeutic effect of taurine in congestive heart failure: a double-blind crossover trial. Clin Cardiol . 1985;8:276-282.
19 Azuma J, Takihara K, Awata N, et al. Taurine and failing heart: experimental and clinical aspects. Prog Clin Biol Res. 1985;179:195-213.
20 Takihara K, Azuma J, Awata N, et al. Beneficial effect of taurine in rabbits with chronic congestive heart failure. Am Heart J . 1986;112:1278-1284.
21 Azuma J, Takihara K, Awata N, et al. Beneficial effect of taurine on congestive heart failure induced by chronic aortic regurgitation in rabbits. Res Commun Chem Pathol Pharmacol. 1984;45:261-270.
22 Azuma J, Sawamura A, Awata N. Usefulness of taurine in chronic congestive heart failure and its prospective application. Jpn Circ J . 1992;56:95-99.
23 Azuma J, Sawamura A, Awata N. Usefulness of taurine in chronic congestive heart failure and its prospective application. Jpn Circ J . 1992;56:95-99.
24 Caponnetto S, Canale C, Masperone MA, et al. Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. Eur Heart J . 1994;15:1267-1273.
25 Mancini M, Rengo F, Lingetti M, et al. Controlled study on the therapeutic efficacy of propionyl-L-carnitine in patients with congestive heart failure. Arzneimittelforschung . 1992;42:1101-1104.
26 Cacciatore L, Cerio R, Ciarimboli M, et al. The therapeutic effect of L-carnitine in patients with exercise-induced stable angina: a controlled study. Drugs Exp Clin Res . 1991;17:225-235.
27 Pucciarelli G, Mastursi M, Latte S, et al. The clinical and hemodynamic effects of propionyl-L-carnitine in the treatment of congestive heart failure [in Italian; English abstract]. Clin Ther . 1992;141:379-384.
28 Loster H, Miehe K, Punzel M, et al. Prolonged oral L-carnitine substitution increases bicycle ergometer performance in patients with severe, ischemically induced cardiac insufficiency. Cardiovasc Drugs Ther. 1999;13:537-546.
29 Hambrecht R, Hilbrich L, Erbs S, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol . 2000;35:706-713.
30 Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplement oral L-arginine in patients with heart failure. Circulation. 1996;93:2135-2141.
31 Watanabe G, Tomiyama H, Doba N. Effects of oral administration of L-arginine on renal function in patients with heart failure. J Hypertens. 2000;18:229-234.
32 Andrews R, Greenhaff P, Curtis S, et al. The effect of dietary creatine supplementation on skeletal muscle metabolism in congestive heart failure. Eur Heart J. 1998;19:617-622.
33 Schaufelberger M, Swedberg K. Is creatine supplementation helpful for patients with chronic heart failure? Eur Heart J. 1998;19:533-534.
34 Gordon A, Hultman E, Kaijser L, et al. Creatine supplementation in chronic heart failure increases skeletal muscle creatine phosphate and muscle performance. Cardiovasc Res. 1995;30:413-418.
35 Keith ME, Jeejeebhoy KN, Langer A, et al. A controlled clinical trial of vitamin E supplementation in patients with congestive heart failure. Am J Clin Nutr . 2001;73:219-224.
36 Rietbrock N, Hamel M, Hempel B, et al. Efficacy of a standardized extract of fresh Crataegus berries on exercise tolerance and quality of life in patients with congestive heart failure (NYHA II) [in German; English abstract]. Arzneimittelforschung . 2001;51:793-798.
37 Hofman-Bang C, Rehnquist N, Swedberg K, et al. Coenzyme Q 10 as an adjunctive treatment of congestive heart failure. J Am Coll Cardiol. 1992;19:216A.
38 Munkholm H, Hansen HH, Rasmussen K. Coenzyme Q 10 treatment in serious heart failure. Biofactors. 1999;9:285-289.
39 Weihmayr T, Ernst E. Therapeutic effectiveness of Crataegus . Fortschr Med. 1996;114:27-29.
40 Tauchert M. Efficacy and safety of crataegus extract WS 1442 in comparison with placebo in patients with chronic stable New York Heart Association class-III heart failure. Am Heart J. 2002;143:910-915.
41 Watson PS, Scalia GM, Galbraith A, et al. Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure. J Am Coll Cardiol. 1999;33:1549-1552.
42 Werbach MR. Nutritional Influences on Illness [book on CD-ROM]. Tarzana, CA: Third Line Press; 1998.
43 Hardig L, Daae C, Dellborg M, et al. Reduced thiamine phosphate, but not thiamine diphosphate, in erythrocytes in elderly patients with congestive heart failure treated with furosemide. J Intern Med. 2000;247:597-600.
44 Yue QY, Beermann B, Lindstrom B, et al. No difference in blood thiamine diphosphate levels between Swedish Caucasian patients with congestive heart failure treated with furosemide and patients without heart failure. J Intern Med. 1997;242:491-495.
45 Sole MJ, Jeejeebhoy KN. Conditioned nutritional requirements: therapeutic relevance to heart failure. Herz. 2002;27:174-178.
46 Seligmann H, Halkin H, Rauchfleisch S, et al. Thiamine deficiency in patients with congestive heart failure receiving long-term furosemide therapy: a pilot study. Am J Med. 1991;91:151-155.
47 Jeejeebhoy F, Keith M, Freeman M, et al. Nutritional supplementation with MyoVive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction. Am Heart J. 2002;143:1092-1100.
48 Cohen L, Kitzes R. Magnesium sulfate and digitalis-toxic arrhythmias. JAMA. 1983;249:2808-2810.
49 Toffaletti J. Electrolytes, divalent cations, and blood gases (magnesium). Anal Chem. 1991;63:192R-194R.
50 Whang R, Oei TO, Watanabe A. Frequency of hypomagnesemia in hospitalized patients receiving digitalis. Arch Intern Med. 1985;145:655-656.
51 Martin BJ, Milligan K. Diuretic-associated hypomagnesemia in the elderly. Arch Intern Med . 1987;147:1768-1771.
52 Bashir Y, Sneddon JF, Staunton A, et al. Effects of long-term oral magnesium chloride replacement in congestive heart failure secondary to coronary artery disease. Am J Cardiol . 1993;72:1156-1162.
53 Pittler MH, Schmidt K, Ernst E. Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials. Am J Med . 2003;114:665-74.
54 Degenring FH, Suter A, Weber M, et al. A randomised double blind placebo controlled clinical trial of a standardised extract of fresh Crataegus berries (Crataegisan®) in the treatment of patients with congestive heart failure NYHA II. Phytomedicine . 2003;10:363-9.
55 Omran H, Illien S, MacCarter D, et al. D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. Eur J Heart Fail . 2003;5:615-619.
56 Zeng XH, Zeng XJ, Li YY. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol . 2003;92:173-176.
57 Branea I, Gaita D, Dragulescu I, et al. Assessment of treatment with orotate magnesium in early postoperative period of patients with cardiac insufficiency and coronary artery by-pass grafts (ATOMIC). Rom J Intern Med . 2004;37:287-296.
58 Belardinelli R, Mucaj A, Lacalaprice F, et al. Coenzyme Q 10 and exercise training in chronic heart failure. Eur Heart J. 2006 Aug 1. [Epub ahead of print].
59 Nightingale AK, Crilley JG, Pegge NC, et al. Chronic oral ascorbic acid therapy worsens skeletal muscle metabolism in patients with chronic heart failure. Eur J Heart Fail . 2006 Oct 3. [Epub ahead of print]
60 Jayadevappa R, Johnson JC, Bloom BS, et al. Effectiveness of Transcendental Meditation on functional capacity and quality of life of African Americans with congestive heart failure: a randomized control study. Eth Dis. 2007;17:72-77.
61 Berkrot, B. RTRS-Herbal extract promising in heart failure: study. Reuters website. Available at: http://www.reuters.com/article/health-SP-A/idUSN2720388620070327 . Accessed March 27, 2007.
62 Pittler M, Guo R, Ernst E. Hawthorn extract for treating chronic heart failure. Cochrane Database Syst Rev. 2008;CD005312.
63 Stepura OB, Martynow AI. Magnesium orotate in severe congestive heart failure (MACH). Int J Cardiol. 2008 Feb 15.
64 Zick SM, Gillespie B, Aaronson KD. The effect of Crataegus oxycantha special extract WS 1442 on clinical progression in patients with mild to moderate symptoms of heart failure. Eur J Heart Fail. 2008 May 17.
65 Yeh GY, Wayne PM, Phillips RS. Tai Chi exercise in patients with chronic heart failure. Med Sport Sci. 2008;52:195-208.
66 Pullen PR, Nagamia SH, Mehta PK, et al. Effects of yoga on inflammation and exercise capacity in patients with chronic heart failure. J Card Fail. 2008;14:407-413.
67 Gissi-Hf Investigators. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet. 2008 Aug 29. [Epub ahead of print]
68 Nodari S, Triggiani M, Campia U, et al. Effects of n-3 polyunsaturated fatty acids on left ventricular function and functional capacity in patients with dilated cardiomyopathy. J Am Coll Cardiol. 2011;57(7):870-879.
69 Teerlink JR. Mind or body: evaluating mind-body therapy efficacy in heart failure trials. Arch Intern Med. 2011;171(8):758-759.
70 Barrow DE, Bedford A, Ives G, O'Toole L, Channer KS. An evaluation of the effects of Tai Chi Chuan and Chi Kung training in patients with symptomatic heart failure: a randomised controlled pilot study. Postgrad Med J. 2007;83(985):717-721.
71 Horjus DL, Oudman I, van Montfrans GA, Brewster LM. Creatine and creatine analogues in hypertension and cardiovascular disease. Cochrane Database Syst Rev. 2011 Nov 9;11:CD005184.
72 Madmani ME, Solaiman AY, et al. Coenzyme Q10 for heart failure. Cochrane Database Syst Rev. 2013;CD008684.
- Reviewer: EBSCO CAM Review Board
- Review Date: 08/2013 -
- Update Date: 01/10/2014 -
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Copyright © EBSCO Publishing
All rights reserved.