Chronic Fatigue Syndrome
- Impairment in short-term memory or concentration
- Sore throat
- Tender lymph nodes in the neck or armpits
- Muscle pain
- Pain in many joints, without redness or swelling
- Headache of new pattern or severity
- Unrefreshing sleep
- Malaise following exercise, that lasts for more than 24 hours
Proposed Natural Treatments
Essential Fatty Acids
Nicotinamide Adenine Dinucleotide (NADH)
Other Herbs and Supplements
1 Durlach J. Chronic fatigue syndrome and chronic primary magnesium deficiency (CFS and CPMD). Magnes Res . 1992;5:68.
2 Howard JM, Davies S, Hunnisett A. Magnesium and chronic fatigue syndrome [letter]. Lancet . 1992;340:426.
3 Cox IM, Campbell MJ, Dowson D. Red blood cell magnesium and chronic fatigue syndrome. Lancet . 1991;337:757-760.
4 Cleare AJ, Heap E, Malhi GS, et al. Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial. Lancet . 1999;353:455-458.
5 Jeffcoate WJ. Chronic fatigue syndrome and functional hypoadrenia—fighting vainly the old ennui [letter]. Lancet . 1999;353:424-425.
6 Dessein PH, Shipton EA. Hydrocortisone and chronic fatigue syndrome [letter]. Lancet . 1999;353:1618.
7 Baschetti R . Hydrocortisone and chronic fatigue syndrome [letter] Lancet. 1999;353:1618.
8 Rea T, Buchwald D. Hydrocortisone and chronic fatigue syndrome [letter]. Lancet . 1999;353:1618-1619.
9 Shepherd C. Hydrocortisone and chronic fatigue syndrome [letter]. Lancet . 1999;353:1619-1620.
10 Deale A, Chalder T, Wessely S. Commentary on: randomised, double-blind, placebo-controlled trial of fluoxetine and graded exercise for chronic fatigue syndrome. Br J Psychiatry . 1998;172:491-492.
11 Wearden AJ, Morriss RK, Mullis R, et al. Randomised, double-blind, placebo-controlled treatment trial of fluoxetine and graded exercise for chronic fatigue syndrome. Br J Psychiatry . 1998;172:485-490.
12 Lynch S, Fraser J. Fluoxetine and graded exercise in chronic fatigue syndrome [letter]. Br J Psychiatry . 1998;173:353.
13 Everitt BS. Analysis of drop-out data in treatment trials [letter]. Br J Psychiatry . 1998;173:271.
14 Peterson PK, Pheley A, Schroeppel J, et al. A preliminary placebo-controlled crossover trial of fludrocortisone for chronic fatigue syndrome. Arch Intern Med . 1998;158:908-914.
15 Behan PO, Behan WM, Horrobin D. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Acta Neurol Scand . 1990;82:209-216.
16 Warren G, McKendrick M, Peet M. The role of essential fatty acids in chronic fatigue syndrome. A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA. Acta Neurol Scand . 1999;99:112-116.
17 Forsyth LM, Preuss HG, MacDowell AL, et al. Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome. Ann Allergy . 1999;82:185-191.
18 Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of chronic fatigue syndrome. Neuropsychobiology . 1997;35:16-23.
19 Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of chronic fatigue syndrome. Neuropsychobiology . 1997;35:16-23.
20 See DM, Broumand N, Sahl L, et al. In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency patients. Immunopharmacology . 1997;35:229-235.
21 Himmel PB, Seligman TM. A pilot study employing dehydroepiandrosterone (DHEA) in the treatment of chronic fatigue syndrome. J Clin Rheumatol . 1999;5:56-59.
22 Cunha BA. Beta-carotene stimulation of natural killer cell activity in adult patients with chronic fatigue syndrome. CFIDS Chronicle Physicians' Forum . 1993:18-19.
23 Heath M, Klein NC, Cunha BA. Dose dependent effects of beta carotene therapy in chronic fatigue syndrome [abstract]. Clin Res . 1994;42:345A.
24 Peterson PK, Pheley A, Schroeppel J, et al. A preliminary placebo-controlled crossover trial of fludrocortisone for chronic fatigue syndrome. Arch Intern Med . 1998;158:908-914.
25 Martin RWY, Ogston SA, Evans JR. Effects of vitamin and mineral supplementation on symptoms associated with chronic fatigue syndrome with Coxsackie B antibodies. J Nutr Med . 1994;4:11-23.
26 Brouwers FM, Van Der Werf S, Bleijenberg G, et al. The effect of a polynutrient supplement on fatigue and physical activity of patients with chronic fatigue syndrome: a double-blind randomized controlled trial. QJM. 2002;95:677-683.
27 Kuratsune, H. Effect of Kampo Medicine, “Hochu-ekki-to,” on chronic fatigue syndrome. Clinic and Research . 1997;74:1837-1845.
28 Hartz AJ, Bentler S, Noyes R, et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med . 2004;34:51-61.
29 Williams G, Waterhouse J, Mugarza J, et al. Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy. Eur J Clin Invest . 2002;32:831-837.
30 Smith S, Sullivan K. Examining the influence of biological and psychological factors on cognitive performance in chronic fatigue syndrome: a randomized, double-blind, placebo-controlled, crossover study. Int J Behav Med . 2003;10:162-173.
31 McDermott C, Richards SC, Thomas PW, et al. A placebo-controlled, double-blind, randomized controlled trial of a natural killer cell stimulant (BioBran MGN-3) in chronic fatigue syndrome. QJM. 2006 Jun 29 [Epub ahead of print].
32 Edmonds M, McGuire H, Price J. Exercise therapy for chronic fatigue syndrome. Cochrane Database Syst Rev. 2004;(3):CD003200.
33 Health Benefits of Chocolate Revealed. Hull and East Yorkshire Hospitals NHS Trust website. Available at: http://www.hey.nhs.uk/pdf/media/chocolate.pdf . Accessed December 21, 2006.
34 Yiu YM, Ng SM, Tsui YL, et al. A clinical trial of acupuncture for treating chronic fatigue syndrome in Hong Kong.] Zhong Xi Yi Jie He Xue Bao. 2007;5:630-633.
35 White P, Goldsmith K, Johnson A, et al. Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Lancet. 2011 Feb 17. [Epub ahead of print]
36 Ng SM, Yiu YM, et al. Acupuncture for chronic fatigue syndrome: a randomized, sham-controlled trial with single-blinded design. Altern Ther Health Med. 2013;19(4):21-26.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 09/18/2014 -
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Copyright © EBSCO Publishing
All rights reserved.