- Folate —Supplementation Possibly Helpful
- Other Nutrients —Supplementation Possibly Helpful
- St. John's Wort —Decreased Effectiveness of Drug
- Indole-3-Carbinol —Possible Decreased Effectiveness of Drug
- Dong Quai, St. John's Wort —Possible Harmful Interaction
- Rosemary —Possible Harmful Interaction
- Grapefruit Juice —Possible Harmful Interaction
- Resveratrol —Possible Harmful Interaction
- Milk Thistle —Possible Decreased Action of Drug
- Androstenedione —Theoretical Harmful Interaction
- Soy —Probably No Interaction
- Ortho Cyclen
- Ortho Tri-Cyclen
- and others
1 Martinez O and Roe DA. Effect of oral contraceptives on blood folate levels in pregnancy. Am J Obstet Gynecol 128: 255-261, 1977.
2 Steegers-Theunissen RP, Van Rossum JM, Steegers EA, et al. Sub-50 oral contraceptives affect folate kinetics. Gynecol Obstet Invest 1993;36:230-233.
3 Mooij PNM, Thomas CMG, Doesburg WH, et al. Multivitamin supplementation in oral contraceptive users. Contraception 1991;44:277-288.
4 Shojania AM, Hornady G, and Barnes PH. Oral contraceptives and serum-folate level. Lancet 1968;1:1376-1377.
5 Whitehead N, Reyner F, and Lindenbaum J. Megaloblastic changes in the cervical epithelium. Association with oral contraceptive therapy and reversal with folic acid. JAMA 1973;226:1421-1424.
6 Larsson-Cohn U. Oral contraceptives and vitamins: a review. Am J Obstet Gynecol 1975;121:84-90.
7 Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-564.
8 Webb JL. Nutritional effects of oral contraceptive use: a review. J Reprod Med 1980;25:150-156.
9 Rivers JM and Devine M. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-689.
10 Briggs M and Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277.
11 Seelig MS. Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment. Magnes Res 1990;3:197-215.
12 Blum M, et al. Oral contraceptive lowers serum magnesium. Harefuah 1991;3:363-364.
13 Jobst KA, McIntyre M, St. George D, et al. Safety of St John's wort (Hypericum perforatum).Lancet 2000;355:575.
14 A to Z Drug Facts [book on CD-ROM]. 2nd ed. St. Louis, MO: Facts and Comparisons; 2000.
15 Takanaga H, Ohnishi A, Murakami H, et al. Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects. Clin Pharmacol Ther 2000;67:201-214.
16 Gehm BD, McAndrews JM, Chien PY, et al. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci U S A 1997;94:14138-14143.
17 Kim DH, et al. Silymarin and its components are inhibitors of beta-glucuronidase. Biol Pharm Bull 1994;17:443-445.
18 Leder BZ, Longcope C, Catlin DH, et al. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 2000;283:779-782.
19 Martini MC, Dancisak BB, Haggans CJ, et al. Effects of soy intake on sex hormone metabolism in premenopausal women. Nutr Cancer 1999;34:133-139.
20 Gorski JC, Hamman MA, Wang Z, et al. The effect of St. John's Wort on the efficacy of oral contraception [abstract MPI-80]. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, March 24-27 ; Atlanta, GA; 2002.
21 Michnovicz JJ. Increased estrogen 2-hydroxylation in obese women using oral indole-3-carbinol. Int J Obes Relat Metab Disord. 1998;22:227-229.
22 Bradlow HL, Sepkovic DW, Telang NT, et al. Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent. Ann N Y Acad Sci. 1999;889:204-213.
23 Yuan F, Chen DZ, Liu K, et al. Anti-estrogenic activities of indole-3-carbinol in cervical cells: implication for prevention of cervical cancer. Anticancer Res. 1999;19:1673-1680.
24 Meng Q, Yuan F, Goldberg ID, et al. Indole-3-carbinol is a negative regulator of estrogen receptor-alpha signaling in human tumor cells. J Nutr. 2000;130:2927-2931.
25 Pfrunder A, Schiesser M, Gerber S, et al. Interaction of St John's wort with low-dose oral contraceptive therapy: a randomized controlled trial. Br J Clin Pharmacol . 2003;56:683-690.
26 Zhu BT, Loder DP, Cai MX, et al. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis . 1998;19:1821-1827.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 09/18/2014 -
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Copyright © EBSCO Publishing
All rights reserved.