- Folate - Supplementation Possibly Helpful
- Vitamin D - Supplementation Possibly Helpful
- Vitamin K - Supplementation Helpful for Pregnant Women
- Biotin - Supplementation Possibly Helpful, but Take at a Different Time of Day
- St. John's Wort, Dong Quai - Possible Harmful Interaction
- Ginkgo - Possible Harmful Interaction
- Kava, Valerian, Passionflower, Hops - Possible Harmful Interaction
- Glutamine - Theoretical Harmful Interaction
1 Berg MJ, Stumbo PJ, Chenard CA, et al. Folic acid improves phenytoin pharmacokinetics. J Am Diet Assoc 95: 352–356, 1995.
2 Ono H, Sakamoto A, Eguchi T, et al. Plasma total homocysteine concentrations in epileptic patients taking anticonvulsants. Metabolism 46: 959–962, 1997.
3 Kishi T, Fujita N, Eguchi T, et al. Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy. J Neurol Sci 145: 109–112, 1997.
4 Reynolds EH. Mental effects of anticonvulsants, and folic acid metabolism. Brain 91: 197–214, 1968.
5 McNamara J. Drugs effective in the therapy of the epilepsies. As cited in Goodman L and Gilman A. The pharmacological basis of therapeutics, 9th ed. Hardman J, et al., eds. New York: McGraw-Hill, 1996: 472.
6 Reynolds EH, Milner G, Matthews DM, et al. Anticonvulsant therapy, megaloblastic haemopoiesis and folic acid metabolism. Q J Med 35: 521–537, 1966.
7 Berg MJ, Stumbo PJ, Chenard CA, et al. Folic acid improves phenytoin pharmacokinetics. J Am Diet Assoc 95: 352–356, 1995.
8 Lewis DP, Van Dyke DC, Stumbo PJ, et al. Drug and environmental factors associated with adverse pregnancy outcomes. Part I: Antiepileptic drugs, contraceptives, smoking, and folate. Ann Pharmacother 32: 802–817, 1998.
9 Biale Y and Lewenthal H. Effect of folic acid supplementation on congenital malformations due to anticonvulsive drugs. Eur J Obstet Gynecol Reprod Biol 18: 211–216, 1984.
10 Holmes T and Kummerow F. The relationship of adequate and excessive intake of vitamin D to health and disease. J Am Coll Nutr 2: 173–199, 1983.
11 Shils M, et al., eds. Modern nutrition in health and disease. 9th ed. Baltimore: Williams and Wilkins, 1999: 1634.
12 Wahl TO, Gobrity AH, and Lukert BP. Long-term anticonvulsant therapy and intestinal calcium absorption. Clin Pharmacol Ther 30: 506–512, 1981.
13 Cornelissen M, Steegers-Theunissen R, Kolle L, et al. Increased incidence of neonatal vitamin K deficiency resulting from maternal anticonvulsant therapy. Am J Obstet Gynecol 168: 923–928, 1993.
14 Cornelissen M, Steegers-Theunissen R, Kolle L, et al. Supplementation of vitamin K in pregnant women receiving anticonvulsant therapy prevents neonatal vitamin K deficiency. Am J Obstet Gynecol 168: 884–888, 1993.
15 Krause K-H, Bonjour J-P, Berlit P, et al. Biotin status of epileptics. Ann N Y Acad Sci 447: 297–313, 1985.
16 Said HM, Redha R, and Nylander W. Biotin transport in the human intestine: inhibition by anticonvulsant drugs. Am J Clin Nutr 49: 127–131, 1989.
17 Arenz A, Klein M, Fiehe K, et al. Occurrence of neurotoxic 4'-O-methylpyridoxine in Ginkgo biloba leaves, ginkgo medications and Japanese ginkgo food. Planta Med 62: 548–551, 1996.
18 Mizuno N, Kawakami K, and Morita E. Competitive inhibition between 4'-substituted pyridoxine analogues and pyridoxal for pyridoxal kinase from mouse brain. J Nutr Sci Vitaminol (Tokyo) 26: 535–543, 1980.
19 Wada K, Ishigaki S, Ueda K, et al. An antivitamin B 6 , 4'-methoxypyridoxine, from the seed of Ginkgo biloba L. Chem Pharm Bull (Tokyo) 33: 3555–3557, 1985.
20 Yagi M, Wada K, Sakata M, et al. Studies on the constituents of edible and medicinal plants. IV. Determination of 4-O-methylpyridoxine in serum of the patient with gin-nan food poisoning [in Japanese; English abstract]. Yakugaku Zasshi 113: 596–599, 1993.
21 Arenz A, Klein M, Fiehe K, et al. Occurrence of neurotoxic 4'-O-methylpyridoxine in Ginkgo biloba leaves, ginkgo medications and Japanese ginkgo food. Planta Med 62: 548–551, 1996.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 09/18/2014 -
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