Diagnosis of Breast Cancer
- Determine where the cancer has spread
- Detect any cancer cells that are in the ducts
- Determine if cancer has spread to the lymph nodes in the armpit
- Fine needle aspiration —A thin needle is used to remove fluid and/or cells from a breast lump. If the fluid is clear, it may not be checked by a lab.
- Large needle (or core) biopsy—tissue from a suspicious area is removed with a special needle.
- Surgical biopsy —During a surgical biopsy, all or part of a breast lump is removed for lab examination. An incisional biopsy removes a small portion of a large lump, while an excisional biopsy removes the entire lump (usually a small one).
- CT scan of the chest and abdomen
- MRI scan of the chest, abdomen , and bones
- Bone scan —to see if cancer has spread to the bones
- Sentinel lymph node biopsy —to help detect cancer in the lymph nodes and determine how many are affected
- Positron emission tomography–CT (PET/CT) —to help detect distant spread of tumor, especially for locally advanced disease
- Stage 0—Called in situ, meaning within the site of origin, the cancer remains in the breast and has not spread.
- Stage I—Cancer has spread beyond the lobe or duct and invaded nearby tissue. At this stage, the tumor is no larger than two centimeters in size and has not spread beyond the breast.
Stage II—Stage II means one of the following:
- Tumor in the breast is less than two centimeters in size and the cancer has spread to the lymph nodes under the arm, or
- Tumor is between two and five centimeters in size (with or without spread to the lymph nodes under the arm) or
- Tumor is larger than five centimeters but has not spread to the lymph nodes under the arm
- Stage III—The tumor is large (more than five centimeters in size) and the cancer has spread to the lymph nodes. Additionally, the tumor could invade the skin, the chest wall, the nipple, or spread to the lymph nodes in the neck or chest wall (called internal mammary nodes).
- Stage IV—Cancer has spread beyond the breast and lymph nodes to other parts of the body.
Breast cancer. American Cancer Society website. Available at: http://www.cancer.org/acs/groups/cid/documents/webcontent/003090-pdf.pdf. Accessed January 6, 2014.
Breast cancer in men. American Cancer Society website. Available at: http://www.cancer.org/acs/groups/cid/documents/webcontent/003091-pdf.pdf. Accessed January 6, 2014.
Breast cancer in men. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated August 1, 2012. Accessed January 6, 2014.
Breast cancer in women. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated January 3, 2014. Accessed January 6, 2014.
Tumor markers. National Cancer Institute website. Available at: http://www.cancer.gov/cancertopics/factsheet/Detection/tumor-markers. Updated December 7, 2011. Accessed January 6, 2014.
5/11/2009 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Gnerlich JL, Deshpande AD, et al. Elevated breast cancer mortality in women younger than age 40 years compared with older women is attributed to poorer survival in early-stage disease. J Am Coll Surg. 2009;208:341-347.
- Reviewer: Mohei Abouzied, MD, FACP
- Review Date: 12/2014 -
- Update Date: 12/20/2014 -
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
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