Acute Lymphoblastic Leukemia
(Acute Lymphocytic Leukemia; ALL)
|White Blood Cells|
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- Previous chemotherapy or radiation therapy treatment
- Exposure to atomic bomb radiation or nuclear reactor accident
- Exposure to toxic chemicals such as pesticides or benzene (common in agriculture, dye works, and paint manufacturing and use)
- Certain genetic disorders, such as Down syndrome, Bloom syndrome, Fanconi's anemia, ataxia-telangiectasia, neurofibromatosis, Shwachman syndrome, IgA deficiency, and congenital X-linked agammaglobulinemia
- Having a brother or sister with leukemia
- Exposure to x-rays before birth
- Exposure to radiation, including X-rays and CT scans
- Previous chemotherapy or other treatment that weakens the immune system
- Pale skin
- Night sweats
- Easy bruising or bleeding
- Petechiae (flat, pinpoint spots under the skin caused by bleeding)
- Shortness of breath
- Weight loss
- Loss of appetite
- Bone or joint pain
- Stomach pain
- Pain or a feeling of fullness below the ribs
- Painless lumps in the neck, underarms, stomach, or groin
- Swelling of the liver and/or spleen
- Blood tests—assessing number of different blood cells to look for abnormally high or low levels and tests of other substances in the blood that may indicate organ stress
- Bone marrow aspiration and biopsy—to remove and test a portion of bone marrow
- Cytogenetic analysis—a test to look for certain changes of the chromosomes (genetic material) of the lymphocytes; certain genetic abnormalities
- Immunophenotyping—examination of the proteins on cell surfaces and the antibodies produced by the body; to distinguish lymphoblastic from myeloid leukemia and determine types of therapy
- Lumbar puncture—to see if leukemia has spread to spinal cord and brain
- Chest x-ray—look for masses in chest caused by leukemia
Chemotherapy With Stem Cell Transplant
Possible Development of New Cancers
American Cancer Society http://www.cancer.org/
The Leukemia and Lymphoma Society http://www.lls.org/
Canadian Cancer Society http://www.cancer.ca/
Leukemia & Lymphoma Society of Canada http://www.llscanada.org
Acute lymphoblastic leukemia (ALL). EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated October 29, 2012. Accessed October 30, 2012.
Adult acute lymphoblastic leukemia (PDQ): treatment. National Cancer Institute website. Available at: http://www.cancer.gov/cancertopics/pdq/treatment/adultALL/Patient/page1 . Updated July 23, 2012. Accessed October 30, 2012.
Childhood acute lymphoblastic leukemia (PDQ): treatment. National Cancer Institute website. Available at: http://www.cancer.gov/cancertopics/pdq/treatment/childALL/HealthProfessional . Updated October 5, 2012. Accessed October 30, 2012.
Leukemia—Acute lymphocytic (ALL) in adults. American Cancer Society website. Available at: http://www.cancer.org/docroot/CRI/CRI%5F2%5F3x.asp?rnav=cridg&dt=57 . Accessed October 30, 2012.
3/29/2007 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : Hijiya N, Hudsdon MM, Lensing S, et al. Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia. JAMA. 2007;297:1207-1215.
- Reviewer: Mohei Abouzied, MD
- Review Date: 12/2013 -
- Update Date: 01/13/2014 -
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
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