Nuclear Medicine - Bone Marrow

What is Bone Marrow Imaging?

Bone Marrow Imaging is a diagnostic study used to evaluate bone marrow activity in multiple diseases or in bone marrow replacement.

Indication

  • Marrow involvement in infection (99mTc-Sunfur Colloid)
  • Marrow involvement in Metastatic Disease (99mTc-HMPAO/WBC) 
  • Aplastic Anemia (11-In-Chloride) 
  • Myelofibrosis (111-In-Chloride) 
  • Marrow viability post transplant or Radiotherapy (99mTc-HMPAO/WBC)

How do I prep for this procedure

There is no preparation required for this procedure.

What should a patient expect of the procedure?

  • Time in the department is depended on the type of exam being performed.
  • Infection, 99mTc-SC and 111In-WBC you will return to the department multiple times 
    • It will take 5 –10 minutes for a Nuclear Medicine technologist to withdraw 60cc of blood (via a hep-loc) in order to separate your white blood cells from the red and be tagged to an isotope. 
    • You will return 4 hours later to be injected with your WBC which will take 5-8 minutes 
    • You will return 4 hours after injection so the first image can be made, taking 30-50 minutes 
    • You will return 24 hours later for the second image to be made, taking 35-50 minutes 
    • You will receive another isotope (99mTc-SC) and wait 30 minutes before taking an image 
    • You may be imaged for 35-50 minutes using both isotope peak or 1 peak for 15-25 minutes then the other for 15-25 
    • This could be repeated 48 hours later
  • Metastatic involvement and Marrow Viability, 99mTc-HMPAO/WBC – you will return to the department multiple times 
    • It will take 5-10 minutes for the technologist to withdraw 60cc of blood (via hep-loc) in order to separate your WBC from your RBC and tag to the isotope 
    • You will return 4 hours later to be injected with your WBC taking 5-8 minutes 
    • You will return 2 hours after injection for first imaging which will take 20-45 
    • You will return 2 hours after the first image to take the second image which will take 20-45 minutes 
    • This could be repeated 24 hours later
  • Aplastic Anemia and Myelofibrosis, 111In-CL- you will return to the department multiple times 
    • It will take 3-5 minutes for a technologist to inject you with the isotope 
    • You will return 24 hours after your injection for the first image which will take from 35-50 minutes 
    • You will return again 48 hours from the injection for the second image, which will take 35-50 minutes 
    • This could be repeated 72 hours after injection and 96 hours after injection.